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HIV (human immunodeficiency virus) is a virus that attacks the body's immune system and remains a major global health challenge because of persistent viral reservoirs, despite effective treatments. Key factors include around 40 million people living with HIV, 1 million new infect

A tumor is more than its cancer cells. Immune cells, blood vessels and other surrounding tissue influence how a cancer grows and responds to treatment. Two tumors containing the same cell types can respond very differently to the same therapy depending on how those cells are arra

For most healthy people, Cryptococcus is an unnoticed infection. The immune system walls it off in the lungs and keeps it dormant for life. But in patients undergoing cancer chemotherapy, recovering from an organ transplant, living with HIV or taking newer immunosuppressing drugs

The early period of life is a critical phase in which the immune system must learn to tolerate harmless environmental stimuli, such as food and microbes that normally live in and on the body, while remaining vigilant against harmful substances and pathogens. If it fails to strike

An international team of researchers has developed an innovative strategy for producing new vaccines. They created a genetically modified version of the chikungunya virus that replicates only once yet still trains the immune system to defend itself without causing disease. In tes

Beginning around age 50, the brain’s memory center appears to lose many of its longtime immune cells and replace them with more inflammatory ones. This surprising shift may help explain how normal aging sets the stage for Alzheimer’s disease and dementia.

Every time a virus invades a person, it collides with thousands of years of human history. A study led by researchers at the USC Dornsife College of Letters, Arts and Sciences and Howard University suggests that some of the genes involved in the body's immune response today bear

A massive analysis of immune cells in human tissue is yielding clues to the root causes of lung and autoimmune diseases.

A disease surveillance strategy modeled on the body's immune system detected more disease-carrying insects than the traditional top-down approach, according to a study led by researchers from the Perelman School of Medicine at the University of Pennsylvania and the Universidad Pe

A protein that evolved long before the human circulatory system may help unlock stronger cancer treatments. When C3 is produced inside tumors, it blocks immune-suppressing cells and gives immunotherapy a better chance to work. Researchers were even able to recreate this effect in

A new study co-led by professor Valeriya Malysheva, group leader at the VIB-UAntwerp Center for Molecular Neurology, published in Nature Genetics, uncovers how the three-dimensional organization of DNA in rare immune cells can help explain genetic risk for Crohn's disease and oth

One of the many ways obesity harms the human body is through damage to skeletal muscle. This progressive muscle decline, also known as sarcopenia, reduces strength, mobility and the ability to live independently. Unfortunately, most therapies for obesity and related conditions li